特異性

The mouse monoclonal antibody SLAM.4 recognizes CD150 antigen, a cell surface molecule expressed on lymphocytes and involved in their activation.

抗原情報

CD150 (SLAM; signaling lymphocyte activation molecule) is a 70-95 kDa single chain transmembrane phosphoglycoprotein of the CD2 family. Its extracellular part contains eight potential N-glycosylation sites, and the intracellular tail contains three unique tyrosine-based motifs. These binding sites can be recognized by SH2-binding phosphatases and the adaptor proteins, such as SAP/SH2D1A or EAT-2. The SLAM family receptors are involved in leukocytes activation and contribute to the effective germinal center formation, generation of high-affinity antibody-secreting plasma cells, and memory T and B cells, thereby facilitating long-term immune response. CD150 expression is upregulated after cell activation.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• De Salort J, Sintes J, Llinás L, Matesanz-Isabel J, Engel P: Expression of SLAM (CD150) cell‑surface receptors on human B‑cell subsets: from pro‑B to plasma cells. Immunol·Lett. 2011·Jan·30; 134(2):129‑36. <·PMID:·20933013·>
• García VE, Quiroga MF, Ochoa MT, Ochoa L, Pasquinelli V, Fainboim L, Olivares LM, Valdez R, Sordelli DO, Aversa G, Modlin RL, Sieling PA: Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. J·Immunol. 2001·Nov·15; 167(10):5719‑24. <·PMID:·11698444·>
• Romero X, Benítez D, March S, Vilella R, Miralpeix M, Engel P: Differential expression of SAP and EAT‑2‑binding leukocyte cell‑surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue·Antigens. 2004·Aug; 64(2):132‑44. <·PMID:·15245368·>
• Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P: CD229 (Ly{09} lymphocyte cell surface receptor interacts homophilically through its N‑terminal domain and relocalizes to the immunological synapse. J·Immunol. 2005·Jun·1; 174(11):7033‑42. <·PMID:·15905546·>