特異性

The mouse monoclonal antibody UW60.1 recognizes CD209 antigen, a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages.

抗原情報

CD209 (DC-SIGN; dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3).

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Geijtenbeek TB, Engering A, Van Kooyk Y: DC‑SIGN, a C‑type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J·Leukoc·Biol. 2002·Jun; 71(6):921‑31. <·PMID:·12050176·>
• Khoo US, Chan KY, Chan VS, Lin CL: DC‑SIGN and L‑SIGN: the SIGNs for infection. J·Mol·Med. 2008·Aug; 86(8):861‑74. <·PMID:·18458800·>
• Ryan EJ, Marshall AJ, Magaletti D, Floyd H, Draves KE, Olson NE, Clark EA: Dendritic cell‑associated lectin‑1: a novel dendritic cell‑associated, C‑type lectin‑like molecule enhances T cell secretion of IL‑4. J·Immunol. 2002·Nov·15; 169(10):5638‑48. <·PMID:·12421943·>
• van Kooyk Y, Geijtenbeek TB: A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol·Rev. 2002·Aug; 186:47‑56. <·PMID:·12234361·>