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CyFlow CD158d Purified

品番 AT204672
抗体名 Anti-Hu CD158d PURI,mAb#33
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 Purified (BJ561896)
Mouse IgG1 Purified (AS224818)
反応性|交差吸着 Human レーザー
抗原 CD158d, KIR2DL4 最大蛍光波長 -
クローン mAb#33 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot
Immunocytochemistry
Functional assays

Anti-Hu CD158d PURI,mAb#33

特異性

The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d antigen, a 45 kDa NK cell marker. Cell surface expression and function of CD158d depends on genotype of particular individuals.

抗原情報

CD158d (KIR2DL4) is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Goodridge JP, Witt CS, Christiansen FT, Warren HS: KIR2DL4 (CD158d) genotype influences expression and function in NK cells. J·Immunol. 2003·Aug·15; 171(4):1768‑74. <·PMID:·12902476·>
• LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED: HLA‑G up‑regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. FASEB·J. 2005·Apr; 19(6):662‑4. <·PMID:·15670976·>
• Rajagopalan S, Bryceson YT, Kuppusamy SP, Geraghty DE, van der Meer A, Joosten I, Long EO: Activation of NK cells by an endocytosed receptor for soluble HLA‑G. PLoS·Biol. 2006·Jan; 4(1):e9. <·PMID:·16366734·>
• Rajagopalan S, Fu J, Long EO: Cutting edge: induction of IFN‑gamma production but not cytotoxicity by the killer cell Ig‑like receptor KIR2DL4 (CD158d) in resting NK cells. J·Immunol. 2001·Aug·15; 167(4):1877‑81. <·PMID:·11489965·>
• Yan WH, Fan LA: Residues Met76 and Gln79 in HLA‑G alpha1 domain involve in KIR2DL4 recognition. Cell·Res. 2005·Mar; 15(3):176‑82. <·PMID:·15780179·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD158d Purified (mAb–33) AT204672 TDS (US)