研究用フローサイトと理化学分析

世界のリサーチ分野のお客さまへ先端の検査装置のご案内です。

お問い合わせはこちら

sysmex

研究用フローサイトと理化学分析sysmex

CyFlow CD305 PE

品番 AP854966
抗体名 Anti-Hu CD305 PE,NKTA255
包装単位 100 tests
濃度 -
容量 1 ml
関連製品
(アイソタイプコントロール)
Mouse IgG1 PE (BV655324)
反応性|交差吸着 Human レーザー Blue, Green, Yellow
抗原 CD305, LAIR1, LAIR-1 最大蛍光波長 576 nm
クローン NKTA255 最大励起波長 496 nm, 565 nm
ホスト Mouse 標識/Format PE
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry

Anti-Hu CD305 PE,NKTA255

特異性

The mouse monoclonal antibody NKTA255 recognizes CD305 (LAIR1) antigen, a 40 kDa type I transmembrane glycoprotein expressed on NK, T, and B cells, monocytes, dendritic cells, eosinophils, basophils, mast cells, CD34+ hematopoietic progenitor cells and thymocytes.

抗原情報

CD305 (LAIR1; leukocyte-associated Ig-like receptor 1) is an inhibitory receptor found on many types of peripheral blood cells. It serves to suppress cell cytotoxicity, activation, proliferation, and differentiation regarding autoantigens via its two intracellular ITIM sites. CD305 belongs to the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family of proteins. It reacts with collagen ligands.

利用方法

The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Colombo BM, Canevali P, Magnani O, Rossi E, Puppo F, Zocchi MR, Poggi A: Defective expression and function of the leukocyte associated Ig‑like receptor 1 in B lymphocytes from systemic lupus erythematosus patients. PLoS·One. 2012; 7(2):e31903. <·PMID:·22355402·>
• Meyaard L: The inhibitory collagen receptor LAIR‑1 (CD305). J·Leukoc·Biol. 2008·Apr; 83(4):799‑803. <·PMID:·18063695·>
• Poggi A, Pella N, Morelli L, Spada F, Revello V, Sivori S, Augugliaro R, Moretta L, Moretta A: p40, a novel surface molecule involved in the regulation of the non‑major histocompatibility complex‑restricted cytolytic activity in humans. Eur·J·Immunol. 1995·Feb; 25(2):369‑76. <·PMID:·7875198·>
• Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L: p40/LAIR‑1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte‑monocyte colony‑stimulating factor. Eur·J·Immunol. 1998·Jul; 28(7):2086‑91. <·PMID:·9692876·>
• Poggi A, Tomasello E, Revello V, Nanni L, Costa P, Moretta L: p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR‑mediated triggering of T lymphocytes. Int·Immunol. 1997·Sep; 9(9):1271‑9. <·PMID:·9310830·>
• Son M, Santiago-Schwarz F, Al-Abed Y, Diamond B: C1q limits dendritic cell differentiation and activation by engaging LAIR‑1. Proc·Natl·Acad·Sci·USA. 2012·Nov·13; 109(46):E3160‑7. <·PMID:·23093673·>
• Warren HS: The Eighth Human Leucocyte Differentiation Antigen (HLDA8) Workshop: natural killer cell section report. Cell·Immunol. 2005·Jul-Aug; 236(1‑2):17‑20. <·PMID:·16157321·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD305 PE (NKTA255) AP854966 TDS (US)