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CyFlow ABRA1 Purified

品番 AP667270
抗体名 Anti-Hu ABRA1 PURI,ABRA1-01
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
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反応性|交差吸着 Human レーザー
抗原 ABRA1 最大蛍光波長 -
クローン ABRA1-01 最大励起波長 -
ホスト Mouse 標識/Format Purified
アイソタイプ IgG 研究分野 Transcription | Adaptor proteins
クローナリティ monoclonal 用途

Flow cytometry
Immunoprecipitation
Western blot

Anti-Hu ABRA1 PURI,ABRA1-01

特異性

The mouse monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 antigen, an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

抗原情報

ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Liu Z, Wu J, Yu X: CCDC98 targets BRCA1 to DNA damage sites. Nat·Struct·Mol·Biol. 2007·Aug; 14(8):716‑20. <·PMID:·17643121·>
• Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA: Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene. 2009·Apr·23; 28(16):1843‑52. <·PMID:·19305427·>
• Wang B, Elledge SJ: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc·Natl·Acad·Sci·USA. 2007·Dec·26; 104(52):20759‑63. <·PMID:·18077395·>
• Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ: Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007·May·25; 316(5828):1194‑8. <·PMID:·17525340·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ ABRA1 Purified (ABRA1-01) AP667270 TDS (US)