CyFlow CD81 APC-Cy7
| 品番 | AN580880 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD81 APC-CY7,M38 | ||
| 包装単位 | 100 tests | ||
| 濃度 | - | ||
| 容量 | 0.4 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 APC-Cy7 (AQ870020) |
||
| 反応性|交差吸着 | Human | Cat | Rabbit | レーザー | Red |
| 抗原 | CD81, TAPA-1 | 最大蛍光波長 | 780 nm |
| クローン | M38 | 最大励起波長 | 650 nm, 750 nm |
| ホスト | Mouse | 標識/Format | APC-Cy7 |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD81 APC-CY7,M38
特異性
The mouse monoclonal antibody M38 recognizes CD81 antigen, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
抗原情報
CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells, e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ: Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B‑lymphocytes. J·Biol·Chem. 1998·Aug·7; 273(32):20121‑7. <·PMID:·9685355·>
• Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O: Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T‑cell leukemia virus type 1 (HTLV‑1)‑induced syncytium formation: altered glycosylation of C33 antigen in HTLV‑1‑positive T cells. J·Virol. 1992·Mar; 66(3):1394‑401. <·PMID:·1738199·>
• Imai T, Kakizaki M, Nishimura M, Yoshie O: Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J·Immunol. 1995·Aug·1; 155(3):1229‑39. <·PMID:·7636191·>
• Imai T, Yoshie O: C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. J·Immunol. 1993·Dec·1; 151(11):6470‑81. <·PMID:·8245480·>
• Stehlíková O, Chovancová J, Tichý B, Krejčí M, Brychtová Y, Panovská A, Francová Skuhrová H, Burčková K, Borský M, Loja T, Mayer J, Pospíšilová S, Doubek M: Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8‑color flow cytometry protocol in routine hematological practice. Int·J·Lab·Hematol. 2014·Apr; 36(2):165‑71. <·PMID:·24028768·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN