特異性

The mouse monoclonal antibody DDIT-03 recognizes DDIT4L antigen, which belongs to stress-induced proteins involved in mediation of cell death.

抗原情報

DDIT4L (DNA-damage-inducible transcript 4-like), also known as REDD2 (regulated in development and DNA damage response 2) or RTP801L is a stress-inducted protein, which was shown to mediate monocyte cell death through a reduction in thioredoxin-1 expression, and is highly expressed in atherosclerotic lesions. Stimulation of DDIT4L expression in macrophages increases oxidized LDL-induced macrophage death.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Corradetti MN, Inoki K, Guan KL: The stress‑inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J·Biol·Chem. 2005·Mar·18; 280(11):9769‑72. <·PMID:·15632201·>
• Cuaz-Pérolin C, Furman C, Larigauderie G, Legedz L, Lasselin C, Copin C, Jaye M, Searfoss G, Yu KT, Duverger N, Negre-Salvayre A, Fruchart JC, Rouis M: REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. Arterioscler·Thromb·Vasc·Biol. 2004·Oct; 24(10):1830‑5. <·PMID:·15308555·>
• Imen JS, Billiet L, Cuaz-Pérolin C, Michaud N, Rouis M: The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thioredoxin‑1 expression. Free·Radic·Biol·Med. 2009·May·15; 46(10):1404‑10. <·PMID:·19268525·>