CyFlow CD112 PE
| 品番 | AL095410 | ||
|---|---|---|---|
| 抗体名 | Anti-Hu CD112 PE,R2.525 | ||
| 包装単位 | 100 tests | ||
| 濃度 | - | ||
| 容量 | 1 ml | ||
| 関連製品 (アイソタイプコントロール) |
Mouse IgG1 PE (BV655324) |
||
| 反応性|交差吸着 | Human | レーザー | Blue, Green, Yellow |
| 抗原 | CD112, PRR2, Nectin-2, Hve B | 最大蛍光波長 | 576 nm |
| クローン | R2.525 | 最大励起波長 | 496 nm, 565 nm |
| ホスト | Mouse | 標識/Format | PE |
| アイソタイプ | IgG1 | 研究分野 | Immunophenotyping |
| クローナリティ | monoclonal | 用途 | Flow cytometry |
Anti-Hu CD112 PE,R2.525
特異性
The mouse monoclonal antibody R2.525 recognizes CD112 antigen, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors.
抗原情報
CD112 (nectin-2) is a transmembrane glycoprotein involved in organization of adherens junctions. It also serves as a target molecule for entry of certain strains of herpes simplex virus (HSV) and pseudorabies virus (PRV). It is homologous to CD155, which serves as a target molecule for polio virus. CD112 seems to play a role in neural tube formation, with N-cadherin. Inside the cell, CD112 is connected with actin cytoskeleton through afadin. Variations in the CD112 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
利用方法
The reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10 µl reagent / 100 µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
保存方法
Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
安定性情報
Do not use after expiration date stamped on vial label.
レファレンス
• Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule‑1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer·Res. 2007·Feb·1; 67(3):1317‑25. <·PMID:·17283169·>
• Enqvist M, Nilsonne G, Hammarfjord O, Wallin RP, Björkström NK, Björnstedt M, Hjerpe A, Ljunggren HG, Dobra K, Malmberg KJ, Carlsten M: Selenite induces posttranscriptional blockade of HLA‑E expression and sensitizes tumor cells to CD94/NKG2A‑positive NK cells.. J·Immunol. 2011·Oct·1; 187(7):3546‑54. <·PMID:·21890659·>
• Hou S, Ge K, Zheng X, Wei H, Sun R, Tian Z: CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain. J·Biol·Chem. 2014·Mar·7; 289(10):6969‑77. <·PMID:·24451371·>
• Nielsen N, Ødum N, Ursø B, Lanier LL, Spee P: Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA‑1 and TRAIL and dampened via CD94/NKG2A. PLoS·One. 2012; 7(2):e31959. <·PMID:·22384114·>
Available Safety Data Sheets
CyFlow™ monoclonal antibodies SDS CA EN