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CyFlow CD263 Azide Free

品番 AE050786
抗体名 Anti-Hu CD263 AZIDFREE,TRAILR302
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
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反応性|交差吸着 Human レーザー
抗原 CD263, TRAIL-R3, DCR1 最大蛍光波長 -
クローン TRAIL-R3-02 最大励起波長 -
ホスト Mouse 標識/Format Azide Free
アイソタイプ IgG1 研究分野 Immunophenotyping | Apoptosis
クローナリティ monoclonal 用途

Flow cytometry

Anti-Hu CD263 AZIDFREE,TRAILR302

特異性

The mouse monoclonal antibody TRAIL-R3-02 recognizes CD263 (TRAIL-R3) antigen, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.

抗原情報

CD263 (TRAIL-R3, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumor cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain‑mediated ligand‑independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL‑induced apoptosis. Proc·Natl·Acad·Sci·USA. 2005·Dec·13; 102(50):18099‑104. <·PMID:·16319225·>
• Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol·Oncol·Res. 2007; 13(4):290‑4. <·PMID:·18158563·>
• Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling. Int·J·Biochem·Cell·Biol. 2007; 39(7‑8):1462‑75. <·PMID:·17403612·>
• Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL‑mediated DR5‑DISC formation by decoy receptors 1 and 2. Mol·Cell·Biol. 2006·Oct; 26(19):7046‑55. <·PMID:·16980609·>
• Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S: Surface TRAIL decoy receptor‑4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC·Cancer. 2005·May·25; 5(1):54. <·PMID:·18518976·>