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CyFlow CD107a Azide Free

品番 AC942051
抗体名 Anti-H/M CD107A AZIDFREE,H4A3
包装単位 0.1 mg
濃度 1 mg/ml
容量 0.1 ml
関連製品
(アイソタイプコントロール)
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反応性|交差吸着 Human | Mouse | Non-Human Primates レーザー
抗原 CD107a, LAMP-1 最大蛍光波長 -
クローン H4A3 最大励起波長 -
ホスト Mouse 標識/Format Azide Free
アイソタイプ IgG1 研究分野 Immunophenotyping
クローナリティ monoclonal 用途

Flow cytometry
Western blot
Immunohistochemistry
Immunocytochemistry

Anti-H/M CD107A AZIDFREE,H4A3

特異性

The mouse monoclonal antibody H4A3 recognizes CD107a antigen, a 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane.

抗原情報

CD107a (LAMP-1; lysosome-associated membrane protein-1), together with CD107b (LAMP-2), is a major constituent of lysosomal membrane, 1-2 % of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule‑1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer·Res. 2007·Feb·1; 67(3):1317‑25. <·PMID:·17283169·>
• Deetz CO, Hebbeler AM, Propp NA, Cairo C, Tikhonov I, Pauza CD: Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T‑cell receptor plus the Toll‑Like receptor 2 agonist Pam3Cys. Infect·Immun. 2006·Aug; 74(8):4505‑11. <·PMID:·16861636·>
• Furuta K, Ikeda M, Nakayama Y, Nakamura K, Tanaka M, Hamasaki N, Himeno M, Hamilton SR, August JT: Expression of lysosome‑associated membrane proteins in human colorectal neoplasms and inflammatory diseases. Am·J·Pathol. 2001·Aug; 159(2):449‑55. <·PMID:·11485903·>
• Mane SM, Marzella L, Bainton DF, Holt VK, Cha Y, Hildreth JE, August JT: Purification and characterization of human lysosomal membrane glycoproteins. Arch·Biochem·Biophys. 1989·Jan; 268(1):360‑78. <·PMID:·2912382·>
• Mao H, Tu W, Liu Y, Qin G, Zheng J, Chan PL, Lam KT, Peiris JS, Lau YL: Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. J·Virol. 2010·May; 84(9):4148‑57. <·PMID:·20164232·>
• Marcenaro S, Gallo F, Martini S, Santoro A, Griffiths GM, Aricó M, Moretta L, Pende D: Analysis of natural killer‑cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13‑4 defect and discriminates between genetic subtypesof the disease. Blood. 2006·Oct·1; 108(7):2316‑23. <·PMID:·16778144·>
• Tomescu C, Chehimi J, Maino VC, Montaner LJ: NK cell lysis of HIV‑1‑infected autologous CD4 primary T cells: requirement for IFN‑mediated NK activation by plasmacytoid dendritic cells. J·Immunol. 2007·Aug·15; 179(4):2097‑104. <·PMID:·17675468·>
• Yu CI, Gallegos M, Marches F, Zurawski G, Ramilo O, García-Sastre A, Banchereau J, Palucka AK: Broad influenza‑specific CD8+ T‑cell responses in humanized mice vaccinated with influenza virus vaccines. Blood. 2008·Nov·1; 112(9):3671‑8. <·PMID:·18713944·>

Available Safety Data Sheets

CyFlow™ monoclonal antibodies SDS CA EN

Available Technical Data Sheets

CyFlow™ CD107a Azide Free (H4A3) AC942051 TDS (US)