特異性

The mouse monoclonal antibody AK2 recognizes CD42b antigen, a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.

抗原情報

CD42b (GPIb α) composes together with GPIb β, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.

利用方法

保存方法

Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.

安定性情報

Do not use after expiration date stamped on vial label.

レファレンス

• Vettore S, Scandellari R, Moro S, Lombardi AM, Scapin M, Randi ML, Fabris F: Novel point mutation in a leucine‑rich repeat of the GPIb alpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard‑Soulier syndrome affecting two unrelated families: the N41H variant. Haematologica. 2008·Nov; 93(11):1743‑7. <·PMID:·18815197·>
• Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL: Platelet‑targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J·Thromb·Haemost. 2012·Nov; 10(11):2344‑53. <·PMID:·22978514·>